Table of Contents 1 79

Journal of NeuroEngineering and Rehabilitation

Blank Page 9
Blank Page 10
S1.pdf 11
Funding 11
About this supplement 11
Authors’ contributions 12
Ethics approval and consent to participate 12
Consent for publication 12
Competing interests 12
Publisher’s Note 12
Author details 12
S2.pdf 13
Abstract 13
Background 13
Methods 13
Results 13
Conclusion 13
Background 14
Methods 14
Data source and study population 14
Statistical analysis 14
Results 14
Dysvascular TFA, N = 107 15
TFA due to trauma or cancer, N = 55 15
TFA (Dysvascular and trauma/Cancer) with prosthesis, N = 70 15
Discussion 15
Conclusion 18
Funding 18
Availability of data and materials 18
About this supplement 18
Authors’ contributions 18
Ethics approval and consent to participate 18
Consent for publication 18
Competing interests 18
Publisher’s Note 18
Author details 19
References 19
S3.pdf 20
Abstract 20
Background 20
Methods 20
Results 20
Conclusion 20
Background 21
Methods 21
Literature search 21
Quality assessment 22
Results 23
Discussion 25
Limitations 71
Conclusions 28
Additional file 28
Abbreviations 28
Acknowledgements 36
Funding 28
Availability of data and materials 28
About this supplement 36
Authors’ contributions 28
Authors’ information 28
Ethics approval and consent to participate 28
Consent for publication 28
Competing interests 28
Publisher’s Note 28
Author details 28
References 28
S4.pdf 30
Abstract 30
Background 30
Methods 30
Results 57
Conclusions 30
Trial registration 30
Background 31
Methods 31
Results 33
Discussion 34
Conclusions 59
Abbreviations 36
Acknowledgements 36
Funding 36
Availability of data and materials 36
About this supplement 36
Authors’ contributions 36
Ethics approval and consent to participate 36
Consent for publication 36
Competing interests 36
Publisher’s Note 36
References 36
S5.pdf 37
Abstract 37
Background 37
Methods 37
Results 37
Conclusions 37
Background 38
Methods 39
Subjects 39
Measurements 39
Data processing 39
Calculation of temporal symmetry 39
Calculation of loading symmetry 39
Statistical analysis 40
Results 40
Question Q1 40
Question Q2 40
Question Q3 41
Questions Q4-Q6 41
Discussion 42
Question Q1 42
Question Q2 44
Question Q3 45
Question Q4 45
Question Q5 46
Question Q6 46
Conclusions 47
Abbreviations 47
Funding 47
Availability of data and materials 47
About this supplement 47
Authors’ contributions 47
Ethics approval and consent to participate 47
Consent for publication 47
Competing interests 47
Publisher’s Note 48
References 48
S6.pdf 49
Abstract 49
Background 49
Aim 49
Methods 49
Results 49
Conclusion 49
Background 50
Methods 50
Participants 50
Procedure 51
Data collection 51
Data analysis 51
Statistics 52
Results 52
Discussion 53
Conclusion 55
Acknowledgements 55
Ethics approval and consent for participation 55
Funding 55
About this supplement 18
Authors’ contributions 55
Consent for publication 55
Competing interests 55
Publisher’s Note 55
Author details 55
References 28
S7.pdf 57
Abstract 57
Background 57
Methods 57
Results 57
Conclusions 68
Background 58
Methods 58
Target population 58
Data sources 59
Literature review 59
Expert panel process 59
Cost of device acquisition 59
Simulation model 59
Results 59
Clinical benefits 59
Physical function 59
Falls and fall-related mortality 61
Incidence of osteoarthritis 61
Quality of life 61
Economic benefits 62
Direct healthcare cost and indirect cost 62
Cost of device acquisition 62
Total cost 62
Combining economic and clinical benefits 63
Discussion 63
Limitations 64
Conclusions 64
Additional file 64
Abbreviations 64
Acknowledgments 65
Funding 65
Availability of data and materials 65
About this supplement 65
Authors’ contributions 65
Authors’ information 65
Ethics approval and consent to participate 65
Consent for publication 65
Competing interests 65
Publisher’s Note 65
Author details 65
References 65
S8.pdf 68
Abstract 68
Background 68
Methods 68
Results 37
Conclusions 68
Background 69
Methods 69
Developing patient cohorts 69
Developing episodes of care 70
Calculating descriptive statistics and analyzing impact of orthotic/ prosthetic devices on overall patient Medicare expenditures 39
Results 59
Demographic analysis 71
Outcomes analysis: lower extremity orthoses 72
Outcomes analysis: spinal orthoses 73
Outcomes analysis: lower extremity prostheses 74
Discussion 75
Limitations 78
Conclusion 78
Codes used to identify the etiological diagnoses of interest for the orthotic and prosthetic models are included in a separate technical methodology available from the authors. 78
Abbreviations 78
Acknowledgements 78
Funding 78
Availability of data and materials 78
About this supplement 78
Authors’ contributions 79
Ethics approval and consent to participate 55
Consent for publication 79
Competing interests 79
Publisher’s Note 79
References 79

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