Cutting Edge Glaucoma - Issue 2

MINIATURIZATION IN GLAUCOMA MONITORING AND TREATMENT: A REVIEW OF NEW TECHNOLOGIES THAT REQUIRE... • 49  Table 1: A summary of the miniaturized devices used in glaucoma management (samples). Diagnostics Eyemate (Argos) (Implandata, Hannover, Germany) Wireless IOP sensor, implanted in sulcus CE marked Intraocular sustained antiglaucomatous drug release Bimatoprost SR ((Allergan) Biodegradable implant Contains bimatoprost Placed in anterior chamber Currently in phase III trials ENV515 (Envisia Therapeutics, Durham, NC, U.S.A.) Biodegradable implant Contains travoprost Placed in anterior chamber Currently in phase 2a trials iDose (Glaukos Corp., Laguna Hills, CA, U.S.A.) Titanium implant, to be replaced when depleted Contains travoprost Placed in anterior chamber Phase 3 trial announced for 2018 Drug delivery device by Amorphex Therapeutics Biodegradable material Placed on the sclera underneath eyelid Currently in phase 2a trials, containing a prostaglandin Minimally invasive glaucoma surgery (MIGS), implants Trabecular outflow iStent (Glaukos Corp., Laguna Hills, CA, U.S.A.) FDA approved CE marked iStent inject (Glaukos Corp., Laguna Hills, CA, U.S.A.) Investigational in the U.S., FDA approval expected for second half of 2018 CE marked Hydrus (Ivantis Inc., Irvine, CA, U.S.A.) Investigational in the U.S. CE marked Uveoscleral outflow CyPass (Alcon, Fort Worth, TX, U.S.A.) FDA approved CE marked Worldwide recall from market in 2018 due to safety concerns iStent Supra (Glaukos Corp., Laguna Hills, CA, U.S.A.) Investigational in the U.S. CE marked Subconjunctival outflow XEN Gel (Allergan, Dublin, Ireland) Ab interno FDA approved InnFocus (Santen, Osaka, Japan) Ab externo CE marked Information in the table is accurate as of May 2018. The table is not intended to provide a full summary of all miniaturized devices used in glaucoma management. Data on approval or investigational status depends in most cases on information provided by the manufacturers. remote control in its current design. The same reader unit picks up the digital data relayed by the transponder unit and subsequently displays the IOP values on its light-emitting diode display. The reader and the transponder unit need to be brought into close proximity with each other