Cutting Edge Glaucoma - Issue 2

34 • CUTTING EDGE - GLAUCOMA 21.4 9.7 12.4 14.3 15.1 15.7 15.2 15.3 14.9 14.3 15.2 −53.8 −40.9 −32.6 −28.2 −25.0 −27.2 −27.3 −29.3 −31.6 −27.8 −100 −90 −80 −70 −60 −50 −40 −30 −20 0 5 10 15 20 25 30 Preop 202 Day 1 202 Week 1 193 Week 2 169 Month 1 187 Month 3 184 Month 6 186 Month 9 148 Month 12 178 Month 18 163 Month 24 161 Mean % change in IOP Mean IOP (mmHg) Mean IOP (mmHg) Mean % change in IOP a Eyes, n a b 1.0 1.1 Mean meds 2.7 0 0.1 0.2 0.3 0.5 0.7 0.8 0.9 1.2 1.2 (SD) 0.9 0.2 0.4 0.6 0.8 0.9 1.1 1.1 1.1 −1.7 −1.5 Mean med change a −2.6 −2.6 −2.5 −2.4 −2.1 −1.9 −1.9 −1.7 1.3 1.4 (SD) 0.9 1.0 1.0 1.2 1.2 1.3 1.2 1.3 21.7 9.6 11.8 13.7 15.6 15.4 15.3 15.9 15.1 14.1 15.4 21.0 9.9 13.1 15.2 14.6 16.0 15.2 14.6 14.7 14.5 14.9 −55.3 −44.0 −36.4 −27.2 −27.3 −27.6 −25.4 −29.6 −33.2 −28.2 −51.9 −37.0 −27.5 −29.6 −22.2 −26.6 −29.4 −29.1 −30.0 −27.2 −100 −90 −80 −70 −60 −50 −40 −30 −20 0 5 10 15 20 25 30 Preop Day 1 Week 1 Week 2 Month 1 Month 3 Month 6 Month 9 Month 12 Month 18 Month 24 Mean % change in IOP Mean IOP (mmHg) Implant alone Phaco + implant Implant alone a Phaco + implant a 1.1 1.2 Mean meds 2.7 0 0.1 0.1 0.3 0.5 0.8 0.9 0.9 Eyes, n 114 88 114 88 108 85 97 72 105 82 101 83 105 81 77 71 97 81 84 79 86 75 0.9 1.0 2.5 0 0.1 0.3 0.3 0.5 0.7 0.6 0.9 1.3 1.2 (SD) 0.9 0.3 0.4 0.5 0.9 1.0 1.2 1.2 1.1 1.0 1.0 0.9 0.1 0.4 0.7 0.7 0.9 1.0 0.9 1.0 Mean med change a − 1.6 − 1.5 − 2.7 − 2.7 − 2.6 − 2.5 − 2.2 − 2.0 − 1.8 − 1.8 − 1.7 − 1.5 − 2.5 − 2.4 −2.2 − 2.2 − 2.0 − 1.8 − 1.9 − 1.6 1.4 1.5 (SD) 0.9 1.0 1.0 1.2 1.2 1.3 1.3 1.3 1.2 1.2 0.9 0.9 1.0 1.2 1.2 1.3 1.1 1.2 Fig. 2 Mean and changes in mean IOP and number of IOP-lowering medications from preoperative baseline over time in the mITT population ( a ) and implant alone vs. phaco + implant groups ( b ). IOP, intraocular pressure; meds, medications; mITT, modified intent-to-treat; phaco, phacoemulsification with intraocular lens replacement; preop, preoperative; SD, standard deviation. a P < 0.001 at all postoperative visits Graefes Arch Clin Exp Ophthalmol (2019) 257:983 – 996 989 Fig. 2: Mean and changes in mean IOP and number of IOP-lowering medications from preoperative baseline over time in the mITT population ( a ) and implant alone vs. phaco + implant groups ( b ). IOP , intraocular pressure; meds, medications; mITT , modified intent-to-treat; phaco , phacoemulsification with intraocular lens replace- ment; preop , preoperative; SD , standard deviation. a P < 0.001 at all postoperative visits