Cutting Edge Glaucoma - Issue 2

Abstract Purpose To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG). Methods In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18–33 mmHg on 1–4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medica- tion count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Results The modified intent-to-treat population included 202 eyes (of 218 implanted). Changes (standard deviation) in mean IOP and medication count from baseline were − 6.5 (5.3) mmHg Two-year Results of aMulticenter Study of the Ab Interno Gelatin Implant inMedically Uncontrolled Primary Open-angle Glaucoma Herbert Reitsamer 1 , Chelvin Sng 2,3,4 , VanessaVera 5 , Markus Lenzhofer 1 , Keith Barton 2,3 , Ingeborg Stalmans 6 , For The Apex Study Group Results from interim analyses were presented in part at: American Glaucoma Society 2016 Annual Meeting, March 3–6, 2016, Fort Lauderdale, FL, U.S.A.; American Society of Cataract and Refractive Surgery (ASCRS) Symposium and Congress, May 6–10, 2016, New Orleans, LA, U.S.A.; European Association for Vision and Eye Research Conference, October 5–8, 2016, Nice, France; and 12th European Glaucoma Society Congress, June 19–22, 2016, Prague, Czech Republic. Chelvin Sng e-mail: chelvin@gmail.com 1 Department of Ophthalmology and Optometry, University Clinic Salzburg, SALK/Paracelsus Medical University, Salzburg, Austria 2 Moorfields Eye Hospital, London, UK 3 Department of Ophthalmology, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228, Singapore 4 Singapore Eye Research Institute, Singapore, Singapore 5 Department of Ophthalmology, Unidad Oftalmologica de Caracas, Caracas, Venezuela 6 Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium