MMPAD Milan Meeting Report

22 European Roadshow - Milan, 29 June 2018 MEETING REPORT REFERENCES 1. Patterson C, Guariguata L, Dahlquist G, et al. Diabetes in the young - a global view and worldwide estimates of numbers of children with type 1 diabetes. Diabetes Res Clin Pract . 2014;103(2):161-75. 2. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383(9911):69-82. 3. Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care . 2015;38(10):1964-74. 4. Watkins RA, Evans-Molina C, Blum JS, DiMeglio LA. Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review. Transl Res . 2014;164(2):110-21 5. Pociot F, Lernmark Å. Genetic risk factors for type 1 diabetes. Lancet . 2016;387(10035): 2331-9. 6. Ziegler AG, Bonifacio E, Powers AC, et al. Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease. Diabetes . 2016;65(11):3233-9. 7. Wolfsdorf JI, Allgrove J, Craig ME, et al. ISPAD Clinical Practice Consensus Guidelines 2014. Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatric Diabetes . 2014;15(Suppl. 20):154–79. 8. Dabelea D, Rewers A, Stafford JM, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study. Pediatrics. 2014; 133(4): e938–e945. 9. Cherubini V, Pintaudi B, Rossi MC, et al. Severe hypoglycemia and ketoacidosis over one year in Italian pediatric population with type 1 diabetes mellitus: a multicenter retrospective observational study. Nutr Metab Cardiovasc Dis . 2014;24(5):538- 46. 10. Cherubini V, Skrami E, Ferrito L, et al. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004-2013. Sci Rep . 2016;6:38844. 11. Rabbone I et al. Raccomandazioni per la gestione della chetoacidosi diabetica in età pediatrica. Acta Biomed . 2015; 86:5-26 12. Kuppermann N, Ghetti S, Schunk JE, et al. Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis. N Engl J Med . 2018;378:2275-87. 13. Vanelli M, Chiari C, Ghizzoni L, et al. Effectiveness of a prevention program for diabetic ketoacidosis in children. An 8-year study in schools and private practices. Diabetes Care . 1999;22:7-9. 14. Albanese-O’Neill A, Wu M, Miller KM,et al. Poor adherence to ketone testing in patients with Type 1 Diabetes. Diabetes Care . 2017;40:e38-e39. 15. Ly TT, Maahs DM, Rewers A, et al. ISPAD Clinical Practice Consensus Guidelines 2014. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diab . 2014;15 (suppl. 20):180-92. 16. Saggar M, Tsalikian E, Mauras N, et al. Compensatory hyperconnectivity in developing brains of young children with Type 1 Diabetes. Diabetes . 2017;66:754–62. 17. McMahon SK, Ferreira LD, Ratnam N, et al. Glucose requirements to maintain euglycemia after moderate-intensity afternoon exercise in adolescents with type 1 diabetes are increased in a biphasic manner. J Clin Endocrinol Metab . 2007;92:963-968. 18. Miciulis CP, Mascarenhas LP, Boguszewski MC, Campos WD. Physical activity in children with type 1 diabetes. J Pediatr . 2010;86 (4):271-8 19. Raccomandazioni Italiane per la prevenzione e la gestione delle ipoglicemie nel diabete di tipo 1 in età pediatrica. Acta Biomedica . 2018;89:1-34. 20. Marshall SM. Recent advances in diabetic nephropathy. Postgrad Med J. 2004; 80(949):624-33. 21. Gross J, de Azevedo MJ, Silveiro SP. Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care. 2005;28(1):164-76. 22. Har RL, Reich HN, Scholey JW, et al. The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes. PloS One. 2014;13;9(11):e111131. 23. Currie G, McKay G, Delles C. Biomarkers in diabetic nephropathy: Present and future. World J Diabetes . 2014;5(6):763-76. 24. Danne T, Bangstad HJ, Deeb L, et al. ISPAD Clinical Practice Consensus Guidelines 2014. Insulin treatment in children and adolescents with diabetes. Pediatr Diabetes. 2014;15 (Suppl. 20):115– 34.